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Int J Aging. 2023;1: e10.
doi: 10.34172/ija.2023.e10
  Abstract View: 546
  PDF Download: 341

Original Article

The Predictive Role of Age and the Systemic Inflammation Indexes on ICU Admission and Mortality in Patients with COVID-19

Peiman Foroughi 1 ORCID logo, Mojtaba Varshochi 2 ORCID logo, Mehdi Hassanpour 3 ORCID logo, Behnam Amini 4,5 ORCID logo, Zeinab Nikniaz 6* ORCID logo, Hassan Amini 4,7* ORCID logo

1 Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
5 School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran
6 Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
7 Department of General Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Authors: Zienab Nikniaz, Email: Znikniaz@hotmail.com; Hassan Amini, Email: Hasanaminitbz@gmail.com

Abstract

Objectives: This study was conducted to collect evidence that specified the role of demographic findings (emphasizing age) and systemic inflammatory indicators in the coronavirus disease 2019 (COVID-19) and the outcome of disease which could help clinicians to predict mortality and intensive care unit (ICU) admission of COVID-19 patients.

Design: A retrospective cohort study.

Setting (s): Tabriz, the capital city of the East Azerbaijan Province in northwestern Iran.

Participants: This retrospective cohort study involved analyzing the medical records of 311 COVID-19 patients from 22 July, 2020 to 22 August, 2020.

Outcome measures: The demographic, clinical, and laboratory data and outcomes such as death, ICU admission, and discharge were extracted from medical records and electronic case records.

Results: The analysis of collected data revealed that the average age of non-survivor patients was 68.53±14.68 which was significantly higher than that of survivor patients (59.30±16.44). Furthermore, the comparison of data showed that ischemic heart disease (IHD), respiratory diseases, hemoglobin, derived neutrophil-to-lymphocyte ratio (dNLR), NLR, platelet-to-lymphocyte ratio (PLR), and lactate dehydrogenase (LDH) were higher in non-survivors and ICU admitted patients than in survivors and non-ICU admitted patients. Moreover, multivariate logistic regression analysis indicated that only hypertension (Odds ratio [OR]: 3.18, P=0.02) is an independent risk factor of death in COVID-19 patients, and PLR (OR: 1.02, P=0.05), hypertension (OR: 4.00, P=0.002), and IHD (OR: 5.15, P=0.008) were independent risk factor of ICU admission in COVID-19 patients.

Conclusions: Elderly patients were at higher risk of death and ICU admission compared to others. Further, demographic characteristics and systemic inflammatory indicators were valuable factors for predicting mortality and ICU admission of COVID-19 patients. Collective data regarding the role of demographic characteristics and systemic inflammation indicators for predicting disease outcomes provide strong evidence for the clinical use of these indicators prospectively.


Please cite this article as follows: Foroughi P, Varshochi M, Hassanpour M, Amini B, Nikniaz Z, Amini H. The predictive role of age and the systemic inflammation indexes on ICU admission and mortality in patients with COVID-19. Int J Aging. 2023;1: e10. doi: 10.34172/ija.2023.e10
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Abstract View: 547

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PDF Download: 341

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Submitted: 07 Feb 2023
Revision: 16 Apr 2023
Accepted: 17 Apr 2023
ePublished: 17 Jun 2023
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