Tabriz Valiasr International Hospital Publication International Journal of Aging 2980-9827 4 1 2026 01 01 Clozapine for Treatment of Polydipsia and Hyponatremia in Chronic Schizophrenia Patients: A Systematic Review e9123 e9123 10.34172/ija.9123 EN Parinaz Kalejahi https://orcid.org/0000-0002-5473-171X Ali Asgharzadeh Zahra Mousavi https://orcid.org/0000-0002-5719-7989 Journal Article 10.34172/ija.9123 2025 08 06 2025 11 20 Objectives: T Systematic review of evidence regarding the effect of clozapine on binge drinking and hyponatremia in patients with schizophrenia. Design: systematic review. Setting(s): Schizophrenia patients. Participants: 8 studies. Interventions: Clozapine treatment. Outcome Measures: polydipsia and hyponatremia. Results: Based on the findings, clozapine treatment was consistently associated with significant improvements in both polydipsia and hyponatremia among patients with schizophrenia or schizoaffective disorder. Conclusions: Clozapine appears to consistently ameliorate the dysregulation of thirst and sodium balance in patients with schizophrenia. These findings support the potential of clozapine as a promising targeted therapy and pharmacological strategy and provide a basis for future mechanistic and controlled efficacy studies in this challenging clinical domain, potentially informing evidence-based management of polydipsia-related hyponatremia.