Abstract
Objectives: T Systematic review of evidence regarding the effect of clozapine on binge drinking and hyponatremia in patients with schizophrenia.
Design: systematic review.
Setting(s): Schizophrenia patients.
Participants: 8 studies.
Interventions: Clozapine treatment.
Outcome Measures: polydipsia and hyponatremia.
Results: Based on the findings, clozapine treatment was consistently associated with significant improvements in both polydipsia and hyponatremia among patients with schizophrenia or schizoaffective disorder.
Conclusions: Clozapine appears to consistently ameliorate the dysregulation of thirst and sodium balance in patients with schizophrenia. These findings support the potential of clozapine as a promising targeted therapy and pharmacological strategy and provide a basis for future mechanistic and controlled efficacy studies in this challenging clinical domain, potentially informing evidence-based management of polydipsia-related hyponatremia.